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医学翻译-C/EBPβ控制运动诱导的心肌增生并预防病理性心肌重塑

发布者:鑫达医学翻译 发布时间:2011-01-02阅读:

Title: C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling.
Author: Bostr?m P, Mann N, Wu J et al
Cell. 2010 Dec 23;143(7):1072-83.
PMID: 21183071

Abstract: The heart has the ability to grow in size in response to exercise, but little is known about the transcriptional mechanisms underlying physiological hypertrophy. Adult cardiomyocytes have also recently been proven to hold the potential for proliferation, a process that could be of great importance for regenerative medicine. Using a unique RT-PCR-based screen against all transcriptional components, we showed that C/EBPβ was downregulated with exercise, whereas the expression of CITED4 was increased. Reduction of C/EBPβ in vitro and in vivo resulted in a phenocopy of endurance exercise with cardiomyocyte hypertrophy and proliferation. This proliferation was mediated, at least in part, by the increased CITED4. Importantly, mice with reduced cardiac C/EBPβ levels displayed substantial resistance to cardiac failure upon pressure overload. These data indicate that C/EBPβ represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/EBPβ is a central signal in physiologic hypertrophy and proliferation.


C/EBPβ控制运动诱导的心肌增生并预防病理性心肌重塑
作者:Bostr?m P, Mann N, Wu J等
文献出处:Cell. 2010 Dec 23;143(7):1072-83.
PMID: 21183071
摘要
心脏具备随运动增大的能力,但是生理性肥大下的转录机制并不明确。近来,已证实成体心肌细胞具增殖潜能(增殖对再生医学尤为重要)。利用基于RT-PCR的独特筛检技术对转录成分进行筛检。结果表明,运动后C/EBPβ表达量下调,而CITED4表达量增加。体内与体外条件下C/EBPβ降低均可导致伴有心肌细胞肥大与增生的耐力运动拟表型。该增生过程受CITED4表达量增加的调控,至少一部分是。重要的是,心肌C/EBPβ水平低的小鼠对压力负荷过度后心衰具有较高抗性。这些数据表明C/EBPβ可抑制成体哺乳动物心肌细胞增生与增殖,C/EBPβ水平降低是生理性肥大与增殖的中枢性信号。


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