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Cell杂志刊发免疫学研究新进展

发布者:鑫达医学翻译 发布时间:2012-09-21阅读:

题目:A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread
链接:http://download.cell.com/pdf/PIIS0092867412008896.pdf?intermediate=true
近期发表在细胞学杂志的一篇免疫学文章阐述了淋巴结内的固有免疫应答可限制病原体的传播。
该文章提到:病原体未侵入前,机体通过淋巴网络进行体液及抗原的运输,该系统为一闭合系统。一旦病原体入侵,即可对体液及抗原的运输造成一定的影响。该项研究发现,一系列的淋巴细胞,如NK细胞、γδ T细胞、NKT细胞及 CD8+ T细胞,在发生病原体入侵时,易于于一类巨噬细胞靠近,从而快速获得吞噬细胞给出的信号。该过程将导致淋巴细胞快速分泌γ-干扰素,并导致具抗菌素抗性的巨噬细胞形成。该研究有助于加深对淋巴结定位及胞内信息传递在免疫应答中的理解。
The lymphatic network that transports interstitial fluid and antigens to lymph nodes constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic spread unless dissemination is blocked in the lymph node itself. Here, we show that a network of diverse lymphoid cells (natural killer cells, γδ T cells, natural killer T cells, and innate-like CD8+ T cells) are spatially prepositioned close to lymphatic sinus-lining sentinel macrophages where they can rapidly and efficiently receive inflammasome-generated IL-18 and additional cytokine signals from the pathogen-sensing phagocytes. This leads to rapid IFNγ secretion by the strategically positioned innate lymphocytes, fostering antimicrobial resistance in the macrophage population. Interference with this innate immune response loop allows systemic spread of lymphborne bacteria. These findings extend our understanding of the functional significance of cellular positioning and local intercellular communication within lymph nodes while emphasizing the role of these organs as highly active locations of innate host defense.
该文献为新一期Cell的Featured Article,可见其颇受该杂志的推崇。历来,免疫学在Cell发表的几率就相当高。我们所熟知的免疫拼接机制,就是由日本课题组发表在Cell杂志,该部分内容甚至写入了很多高校的分子生物学教材。
 


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