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医学翻译样例—受试者募集

发布者:鑫达医学翻译 发布时间:2013-05-29阅读:

原文:

Slow trial recruitment was undoubtedly determined by the eligibility criteria: deteriorating renal function in idiopathic membranous nephropathy has become less common with angiotensin-cascade blockade and other aspects of supportive management, and our detailed communications with renal units throughout the UK during the trial showed that the rarity of eligible patients was the main barrier to recruitment. Of the 37 units that entered patients, 31 recruited four patients or fewer. Renal units that declined to participate and apply for ethical approval were roughly equally divided into those concerned about the lack of active therapy in the supportive care only group or the potential toxicity of active therapy-clear evidence that considerable uncertainty surrounds appropriate management of this disorder, and that a definitive RCT is needed.

 

译文:

试验招募进展缓慢毫无疑问是由纳入标准决定的:特发性膜性肾病引起的肾功能恶化不同于血管紧张素释放阻滞及支持疗法的其他方面,我们在试验期间与全英国的肾病研究单位进行深入交流,结果表明合格患者的稀缺性是试验招募的主要障碍。在登记有患者的37家单位中,有31家只招募到4名以下患者。那些基于伦理学批准问题而拒绝参与或申请的肾病研究单位可大体等分为两类:或是关心在仅进行支持治疗的组内缺乏主动性疗法,或是主动疗法存在潜在毒性——围绕怎样恰当处理这种紊乱还有相当多的不确定因素,并且需要权威性的RCT试验,这些都要有明确的证据。


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