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神经内科材料翻译

发布者:鑫达医学翻译 发布时间:2014-07-31阅读:

原文:
Norepinephrine is a monoamine neurotransmitter. Several reports have revealed that norepinephrine is involved in pain modulation of many animals, as well as humans. Norepinephrine are involved in pain modulation via descending inhibitory pathways in the brain and spinal cord. Norepinephrine inhibits peripheral C fibers that transport the noxious stimulation to the spinal cord lateral horn. In central nervous system, the role of norepinephrine through different alpha-adrenergic receptor subtypes changes neuronal excitability and nociceptive information, and modulates the painful response. Previous experiments in our laboratory have revealed that intracerebroventricular injection of norepinephrine produced an analgesic effect. In this study, NE played the role pathway, i.e. the exogenous norepinephrine combined with alpha-adrenergic receptor of PEN or PIN in hippocampal CA3 region, decreased the sensibility of PEN or PIN to noxious stimulus, and caused the bio-electrical activity changes of PEN or PIN, showing analgesic effect of norepinephrine. We demon- strated that intra-hippocampal CA3 region injection of norepinephrine also has a specific antinociceptive effect.

译文: 
去甲肾上腺素是一种单胺类神经递质。多项报道表明,去甲肾上腺素与多种动物及人类的疼痛调节有关。去甲肾上腺素通过降低大脑和脊髓内的抑制途径来调节疼痛。此外,也可抑制外周C纤维将伤害性刺激传递至脊髓外侧角。在中枢神经系统中,去甲肾上腺素通过不同的α-肾上腺素能受体亚型改变神经元兴奋性和感受伤害信息,调节疼痛应答。我们实验室既往的实验表明,脑室内注射去甲肾上腺素可产生镇痛作用。本研究中,去甲肾上腺素发挥作用的途径为:外源性去甲肾上腺素与海马CA3区PEN或PIN的α-肾上腺素能受体结合,降低PEN或PIN对伤害性刺激的敏感性,引起PEN或PIN生物电活动改变,表现为去甲肾上腺素具有止痛作用。我们发现,海马内CA3区注射去甲肾上腺素也有特异性镇痛作用。


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