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骨关节炎文献翻译样例

发布者:鑫达医学翻译 发布时间:2017-09-06阅读:

原文:

Osteoarthritis (OA) is a degenerative joint disease in elderly populations subjected to the impact of mechanical actors and biological factors. These harmful factors cause metabolic imbalance between chondrocyte, extracellular matrix, and subchondral bone. Metabolic imbalance leads to inflammatory mediators and matrix components com- bining with special receptors, then transmitting signals into the nucleus to activate gene transcription, that eventually leads to matrix degradation and cell apoptosis. The pathological nature of OA is the destruction of articular cartilage such as subchondral bone sclerosis, cartilage deg- radation, meniscal degeneration, and osteophytes and sy- novial hyperplasia. Currently, OA has brought consid- erable damage to human health. However, there is still a lack of effective treatment for OA. Therefore, the develop- ment of a novel and effective therapy for OA is of great importance.

 

 

译文:

骨关节炎是一种常发于老年群体、因机械因素与生物因素导致的退行性关节病变。这些因素导致软骨细胞、胞外基质与软骨下骨代谢紊乱,进而促进炎症介质与细胞基质与其特异性受体结合,将信号传递至细胞核内,激活基因转录,最终导致基质降解与细胞凋亡。骨关节炎的病理特征为关节软骨受损,如软骨下骨硬化、软骨退化、半月板退变、骨赘与滑液增生等。如今,骨关节炎给人类健康带来了一定威胁, 但仍缺乏一种有效的治疗方案。因此,建立一种新颖、有效的治疗方案尤为重要!

 

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