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致病性猴免疫缺陷病毒侵染伴随肠道病毒群体的扩张

发布者:鑫达医学翻译 发布时间:2012-10-25 8:50:52 阅读:


猴免疫缺陷病毒(Simian immunodeficiency virus,简称SIV),也称为非洲绿猴病毒(African Green Monkey virus),是一种可影响至少33种非洲灵长目的逆转录病毒,在猴和猿中至少已存在了32000年(http://zh.wikipedia.org/wiki/%E7%8C%B4%E5%85%8D%E7%96%AB%E7%BC%BA%E9%99%B7%E7%97%85%E6%AF%92)。致病性SIV的侵染过程中常伴有肠道疾病,这些肠道疾病似乎加速了猴艾滋病(SAIDS)的发病进程。细胞杂志(cell)最新一期的报道了利用宏基因组技术分析猴免疫病毒侵染伴随的肠道病毒群落情况的研究,此研究来自美国华盛顿大学医学院、麻省理工学院以及哈佛医学院的团队,Scott A. Handley等首先通过第二代测序技术测序获得非人类灵长类动物受SIV侵染过程中肠道病毒群落信息,进而筛选出AIDS肠道病的潜在病原。对比发现,致病性的SIV侵染伴随显著的肠道病毒群落扩张,非致病性的SIV为发现此现象。他们通过病毒培养和PCR检测验证获得了32种伴随致病性SIV侵染出现的以前却未被报道的肠道病毒。其中包括引起肠炎的腺病毒感染以及引起病毒血症的细小病毒感染,它们均出现于AIDS发病之前。令人疑惑的是,他们发现致病性SIV侵染并未引起肠道细菌的明显变化。因此研究者认为肠道病毒感染和AIDS病肠道疾病以及AIDS病发病进城密切。此研究是利用宏基因组技术分析AIDS发病的重要成果,为人类认识AIDS、对抗AIDS提供了新的方向。
 
编译自:
Handley, Scott A., Larissa B. Thackray, et al. (2012). "Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome." Cell 151(2): 253-266.
Summary
Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.
http://www.sciencedirect.com/science/article/pii/S0092867412011683


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