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药学翻译-母体白介素-8含量升高与成年子女精神分裂症发病之间的关系

发布者:鑫达医学翻译公司 发布时间:2011-07-30 8:50:52 阅读:

原文:
Objective: Many studies have implicated prenatal infection in the etiology of schizophrenia. Cytokines, a family of soluble polypeptides, are critically important in the immune response to infection and in other inflammatory processes. The goal of this study was to determine whether second-trimester levels of four cytokines—interleukin-8 (IL-8), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)—are higher in the mothers of offspring who later developed schizophrenia spectrum disorders than in matched comparison subjects. Method: The authors conducted a nested case-control study of maternal serum cytokine levels in a large birth cohort, born 1959–1967. Cases (N=59) were subjects diagnosed with schizophrenia spectrum disorders (mostly schizophrenia and schizoaffective disorder) who had available second-trimester maternal serum samples. Comparison subjects (N=105) were members of the birth cohort, had not been diagnosed with a schizophrenia spectrum disorder or major affective disorder, and were matched to subjects with schizophrenia for date of birth, gender, length of time in the cohort, and availability of maternal sera. Maternal second-trimester serum levels of IL-8, IL-1β, IL-6, and
TNF-α were determined by sandwich enzyme-linked immunosorbent assay. Results: The second-trimester IL-8 levels in mothers of offspring with schizophrenia spectrum disorders were significantly higher than those of the mothers of comparison subjects. There were no differences between subjects with schizophrenia
and comparison subjects with respect to maternal levels of IL-1β, IL-6, or TNF-α. Conclusions: Using prospectively collected prenatal sera in a large and wellcharacterized birth cohort, the authors have documented a significant association between maternal IL-8 level during the second trimester and risk of schizophrenia spectrum disorders in the offspring. These findings provide further support for a substantive role of in utero infection or inflammation in the etiology of schizophrenia. Moreover, these results may have important implications for elucidating the mechanisms by which disrupted fetal development raises the risk of this disorder.

译文:
目的:多项研究已对产前感染在精神分裂症发病中的作用进行了阐述。细胞因子(一类可溶性多肽)在感染及其他炎症的免疫应答过程中发挥重要作用。本研究旨在测定子女出生后患精神分裂症谱系障碍的女性其妊娠中期IL-8、IL-1β、IL-6与肿瘤坏死因子-α的含量是否高于对照组。
方法:作者对某一出生群组(于1959-1967年出生)的母体血清细胞因子水平进行巢式病例对照研究。纳入病例59例,均为子女出生后诊断为精神分裂症谱系障碍(多为精神分裂症与情感性分裂症),且存在妊娠中期血清样本。对照受试者(n=105)源自同一出生群组,且无精神分裂谱系障碍或主要情感失常。此外,对照组与受试者出生日期、性别、年龄阶段及有无血清样本情况相匹配。通过夹心酶联免疫分析测定孕妇妊娠中期血清IL-8、IL-1β、IL-6与TNF-α水平。
结果:子女患神经分裂症谱系障碍的女性妊娠中期血清样本内IL-8水平明显高于对照组。 其他三类细胞因子无明显差异。
结论:我们发现妊娠中期母体血清内IL-8含量与子女患精神分裂症谱系障碍的风险明显相关。该结果为子女后期患精神分裂症源于子宫内感染或炎症提供了有力证据。此外,该结果对阐述胎儿发育受损引发精神分裂障碍风险的机制有重要意义。


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