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精神病学翻译

发布者:鑫达医学翻译公司 发布时间:2011-08-14 8:50:52 阅读:

原文:
The pathogenesis of schizophrenia has yet to be fully characterized. Gene–environment interactions have been found to play a crucial role in the vulnerability to this disease. Among various environmental factors, inflammatory immune processes have been most clearly implicated in the etiology and pathology of schizophrenia. Cytokines, regulators of immune/inflammatory reactions and brain development, emerge as part of a common pathway of genetic and
environmental components of schizophrenia. Maternal infection, obstetric complications, neonatal hypoxia and brain injury all recruit cytokines to mediate inflammatory processes. Abnormal expression levels of specific cytokines such as epidermal growth factor, interleukins (IL) and neuregulin-1 are found both in the brain and peripheral blood of patients with schizophrenia. Accordingly, cytokines have been proposed to transmit peripheral immune/inflammatory signals to immature brain tissue through the developing blood–brain barrier, perturbing structural and phenotypic development of the brain. This cytokine hypothesis of schizophrenia is also supported by modeling experiments in animals. Animals treated with specific cytokines of epidermal growth factor, IL-1, IL-6, and neuregulin-1 as embryos or neonates exhibit schizophrenia-like behavioral abnormalities after puberty, some of which are ameliorated by treatment with antipsychotics. In this review, we discuss the neurobiological mechanisms underlying schizophrenia and novel antipsychotic candidates based on the cytokine hypothesis.

译文:
精神分裂症发病机制尚未明确。其中,基因-环境互作起决定性作用。在这些环境因素中,炎症免疫被认为与精神分裂症的病因学与病理学密切相关。作为免疫/炎症反应与脑发育的调节因子-细胞因子被认为是精神分裂症遗传与环境因素信号通路的一部分。母性感染、产科并发症、新生儿缺氧与脑损伤等过程都会招募细胞因子进行炎症调节。精神分裂患者脑及外周血检测结果表明,特定细胞因子[例如,表皮生长因子(EGF)、白介素(IL)与神经调节蛋白1等]存在表达异常。据此,我们推测细胞因子可穿过发育的血脑屏障(BBB)并将外周免疫/炎症信号传导至未成熟脑组织,进而扰乱脑部结构与表型发育。该假说受到动物模型研究的支持。特定细胞因子(如EGF、IL-1、IL-6及神经调节蛋白-1)处理的动物胚胎或新生儿在其青春期出现类似神经分裂的行为异常。服用安定药物后症状有所减轻。本综述对精神分裂症与基于细胞因子假说的新型安定药物的潜在神经学机制进行讨论。
 


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