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药学翻译-AGEs摄入量与患者身体的关系

发布者:鑫达医学翻译公司 发布时间:2011-09-11 8:50:52 阅读:

原文
Galectin-3 has also been identified as a potentially important mediator of removal of advanced glycosylation end-products (AGEs). AGEs are molecules formed during a nonenzymatic reaction between proteins and sugar residues. They accumulate in the human body with age, but also with enhanced states of oxidative stress, increased intake of AGEs, and renal and heart failure, and are thought to contribute to myocardial stiffening. An AGEspecific cellular receptor complex (AGE-R) mediating AGE removal has been described. Galectin-3 interacts with AGE-R components, thus contributing to the elimination of these pathogenic substances. Galectin-3 disruption is associated with increased susceptibility to AGE-induced renal disease, which indicates that galectin-3 is operating in vivo as an AGE receptor to afford protection toward AGEdependent tissue injury. It remains unknown whether galectin-3 acts on AGE biology in the heart.

译文
AGEs为蛋白质与糖残基非酶反应产生的分子。此外,半乳凝素-3可作为重要的晚期糖基化终末化产物(AGEs)去除介质。其含量随人体年龄增加而增加,并伴有氧化应激加强、AGEs摄入量增加、心衰与肾衰,进而导致心肌僵硬。已有文献报道AGE特定细胞受体复合物(AGE-R)可介导AGE的去除。半乳凝素-3与AGE-R成分互作,进而去除这些致病性物质。 半乳凝素-3结构破坏导致对AGE诱导的肾病易感性增加,表明其在体内作为AGE的受体,保护AGE依赖的组织损伤。半乳凝素-3对心脏AGE生物学活性的影响并不明确。


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