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口腔学翻译

发布者:鑫达医学翻译 发布时间:2013-05-24 8:50:52 阅读:

原文

目的:研究蚌埠地区5年内引起口腔系统药物不良反应的药物流行病学特点,研究引起口腔系统发生不良反应药物的种类和发生率,明确引起口腔系统不良反应的临床表现及其处置和转归,了解引起口腔系统不良反应的主要影响因素。方法:收集蚌埠地区2008年1月~2012年11月期间上报国家药品不良反应监测中心数据库的所有口腔系统不良反应,对发生不良反应的患者人口学资料、原患疾病、联合使用药物、对口腔系统的损害等情况其进行统计、汇总和分析。结果:共收集、整理和上报601例口腔系统药物不良反应病例,4种不同的药物不良反应症状,其中药物引起的口干和口渴540例(占89.85%)、口腔麻木23例(占3.83%)、口腔异味21例(占3.49%)、溃疡性口炎9例(占1.50%)、口腔粘膜损害4例(占0.67%)、口唇发绀3例(占0.50%)、口唇水肿1例(占0.17%)。怀疑的药物共计167个品种,涉及中成药44个品种、消化系统用药29种、抗菌药物21种、抗肿瘤药10种、抗感冒用药8种、维生素类制剂8种、心脑血管系统用药7种。27例为新的药品不良反应,2例为严重不良反应。结论:口腔系统的药物不良反应表现形式是多种多样的,有些药物会造成口干和口渴的一般轻微的不良反应,但有些药物也会造成口腔粘膜的损害导致严重不良反应,所以认识药物不良反应、早期预防和确证以减少不良反应的发生和对患者造成的损害。

 

译文

Objective: To investigate the pharmaceutical epidemiology of adverse drug reactions (ADRs) in oral cavity drugs from January 2008 to November 2012 in Bengbu district, China. To confirm the clinical symptoms, and the treatment and the outcomes of the drugs that resulted in ADRs, based on which to investigate the risk factors of ADRs in oral cavity. Methods: In total, 20600 ADR events affiliated to 601 patients (male: 364, female: 237) were enrolled in this study. Statistical analysis was performed for the demographic information, original diseases, incorporation of drugs, and the lesions of oral cavity. Logistic multiplicity was performed to explore the risk factors for the ADR in oral cavity. Results: Among these events, dry mouth and feeling thirsty (n=540, 89.85%) was the most commonly observed among the patients, followed by oral numbness (n=23, 3.83%), abnormal flavor in oral cavity (n=21, 3.49%), ulcerative stomatitis (n=9, 1.50%), lesion of oral mucosa (n=4, 0.67%), blue jaundice of the lips (n=3, 0.50%), edema of lips (n=1, 0.17%). One hundred sixty seven suspicious drugs were speculated to be associated with ADRs. Twenty seven new ADRs were reported by the patients, among which 2 ADRs were severe. Conclusions: The severity of ADRs in oral cavity varied according to the drugs. A series of indices including age, history of alcohol, incorporation of drugs were the risk factors for the ADR in oral cavity. Therefore, early identification of the ADRs could provide valuable information for the investigation of the demographic information of those may suffer from ADRs, the combination of drugs and the potential injuries of the drugs in oral cavity. 


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