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发布者:鑫达医学翻译公司 发布时间:2011-06-25 8:50:52 阅读:

原文
    The median overall survival was 10.1 months (95% confidence interval [CI], 8.6 to 11.2) in the cetuximab group and 7.4 months (95% CI, 6.4 to 8.3) in the chemotherapy-alone group (hazard ratio for death, 0.80; 95% CI, 0.64 to 0.99; P = 0.04) (Fig. 2A and Table 2). The median follow-up was 19.1 months in the cetuximab group and 18.2 months in the chemotherapy-alone group. Among the patients who were alive at the time of the analysis, the minimum follow-up was 12.9 months and the maximum follow-up was 26.0 months. Sixteen patients (4%) withdrew consent or were lost to follow-up. 
    Median progression-free survival was 5.6 months in the cetuximab group and 3.3 months in the chemotherapy-alone group (hazard ratio for progression, 0.54; 95% CI, 0.43 to 0.67; P<0.001) (Fig. 2B and Table 2). The addition of cetuximab to platinum–fluorouracil chemotherapy was also associated with significant increases in the overall response rate, disease-control rate, and time to treatment failure as compared with platinum–fluorouracil chemotherapy alone (Table 2). The duration of the response in the two groups did not differ significantly. Among the 100 patients
who received cetuximab as maintenance treatment, the median progression-free survival was 12 weeks from the start of maintenance treatment. There were two tumor responses during cetuximab maintenance treatment.

译文 
    西妥昔单抗治疗患者总体中位生存期为10.1个月(95%置信区间为8.6-11.2),而单纯化疗组患者总体中位生存期为7.4个月(死亡危险比0.80,95%置信区间为0.64-0.99,P=0.04),见图2A与表2。西妥昔单抗治疗组随访时间中位数为19.1个月,单纯化疗组随访时间中位数为18.2个月。分析时仍存活患者中,最低随访周期为12.9个月,最高随访周期为26.0个月。 16名患者(占4%)因未签署知情同意,失访。 
    西妥昔单抗治疗组无进展生存中位数为5.6个月,单纯化疗组为3.3个月(进展危害比0.54,95%CI为0.43-0.67,P<0.001),见图2B及表2。与单纯卡铂-氟尿嘧啶化疗组相比,联合使用西妥昔单抗与总缓解率、疾病控制率及治疗失败时间显著提高相关,见表2。两治疗组缓解周期无明显差异。服用西妥昔单抗作为维持治疗的100例患者中,无进展存活中位数为维持治疗起始后12周。西妥昔单抗维持治疗期间出现两例肿瘤缓解情况。

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