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医学翻译-精神病学领域

发布者:鑫达医学翻译公司 发布时间:2011-07-30 8:50:52 阅读:

原文:
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe illnesses representing an enormous social, familiar and individual burden that affect 1% of the population world-wide. Several evidences indicate abnormalities of the dopamine system in both SCZ and BPD. Neuronal calcium sensor-1 (NCS-1) is a protein that has many functions in neurotransmission such as inhibition of dopamine D2 receptor desensitization, regulation of ionic channels and enhancement of exocytosis of neurotransmitters. In addition, NCS-1 protein expression and mRNA levels were found increased in pre-frontal cortex (PFC) of SCZ and BPD patients. NCS-1 expression in neural and neuroendocrine cells is well documented and, recently, itwas shown that NCS-1 is also expressed in mast cells and neutrophils. NCS-1 has important functions in mast cells since it stimulates Fc epsilon RItriggered exocytosis and the release of arachidonic acid metabolites. Then, due to the known close relation between the nervous and immune systems, we sought to investigate the NCS-1 expression in lymphocytes and
monocytes (CD4+ T lymphocytes, CD56+ NK cells, CD19+ B lymphocytes and CD14+ monocytes) of SCZ and BPD patients. Using flow cytometry, our results have shown that NCS-1 expression was diminished in CD4+T lymphocytes, CD19+ B lymphocytes and CD14+ monocytes of BPD patients and also decreased in CD4+ T lymphocytes and CD56+ NK cells of SCZ patients. Results suggest that immune cells might be a cellular model for studies with SCZ and BPD patients considering NCS-1 functions. Efforts need to be done to investigate the motive of the decreased percentage of immune cells expressing NCS-1 in patients with SCZ and BPD.

译文:
精神分裂症(SCZ)与双相情感障碍(BPD)为恶性心理疾病,给社会、家庭及个人带来了沉重的负担。目前全球有1%的人群遭受该疾病的困扰。研究表明SCZ与BPD患者体内多巴胺系统常出现异常。NCS-1蛋白在神经传递过程中发挥重要作用,如抑制多巴胺D2受体钝化,调控离子通道及增强神经递质的胞吐作用等。此外,研究发现SCZ与BPD患者前额皮质(PFC)内NSC-1蛋白表达及mRNA水平上调。相关研究报道神经细胞及神经内分泌细胞内存在NSC-1中表达。近期研究发现肥大细胞与中性白细胞内也存在NSC-1表达。NSC-1可促进肥大细胞内Fc epsilon RI引发的胞吐作用及花生四烯酸代谢产物的释放。针对精神分裂症发病机制方面,神经系统与免疫系统关系密切,但具体机制并不明确。本文对SCZ患者及BPD患者淋巴细胞与单核细胞(如CD4+T淋巴细胞、CD56+NK细胞与CD19+ B淋巴细胞与CD14+单核细胞等)内NSC-1表达开展研究。利用流式细胞术我们发现,BPD患者CD4+T淋巴细胞、CD19+B淋巴细胞及CD14+单核细胞内NSC-1表达降低。同样,SCZ患者CD4+T淋巴细胞及CD56+NK细胞内的NSC-1表达也有所降低。鉴于NCS-1蛋白的功能,本研究的结果表明免疫细胞可作为SCZ与BPD患者研究的模式细胞。欲了解SCZ患者与BPD患者表达NCS-1蛋白的免疫细胞百分比降低机制,需实施进一步研究。


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