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血管科翻译作品展示

发布者:鑫达医学翻译公司 发布时间:2011-10-28 8:50:52 阅读:

原文:
Subjects with hypertension can be subcategorized into two groups: those in whom the increase in blood pressure is secondary to another medical problem or ingestion of exogenous materials, or secondary hypertension, and those in whom the primary pathophysiologic process is elevated blood pressure or primary (essential) hypertension. This chapter focuses on only essential hypertension. In essential hypertension, both hereditary and environmental factors contribute to elevated blood pressure.
From epidemiologic surveys, it has been estimated that approximately 30% of the population variation in SBP can be accounted for by heritability or polygenetic factors. Evidence from twin studies and family cohorts provides heritability estimates as high as 70%. The difference in heritability estimates reflects the diversity of the population under study and the influence of obesity and other environmental factors that interact with genes in producing hypertension. Although the familial gene-frequency distribution in blood pressure is a plausible explanation for the aggregation of blood pressure in families, few studies have unequivocally confirmed that genetic relationships are more important than environmental components of family life.
译文:
高血压的受试者可分为两类:一类是服用其他药物或摄入外源性物质所引发的血压升高,另一类是外源性病理过程引发的血压升高或原发性高血压。本章节仅对原发性高血压进行阐述。在原发性高血压中,遗传因素与环境因素都可导致血压升高。
流行病学调查表明约30%的受试人群收缩压变化是由遗传或多元因素所致。双生研究与家庭世代证实遗传力估计值高达70%。遗传力估计值差异显示受试群体的多样性、与基因互作导致高血压的肥胖与其他环境因素的影响。虽然家族内高血压基因频率分布似乎可对家族内高血压频发进行解释,但是很少有研究明确表明遗传关系比家庭生活环境因素更为重要。


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