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发布者:鑫达医学翻译 发布时间:2013-03-05 8:50:52 阅读:

原文:
We found that three new prophylactic regimens against tuberculosis in HIV-infected adults were not superior to the control regimen of isoniazid therapy for 6 months. The overall rate of tuberculosis was 1.9 cases per 100 person-years, with no significant difference between any of the three new regimens and the control regimen. Among HIVinfected people in Africa with a positive tuberculin skin test who are not receiving antituberculosis treatment, the expected annual rate of tuberculosis ranges from 5 and 10%. The rate of tuberculosis in the control group was also substantially lower than anticipated, suggesting that all the treatments used in this study performed better than regimens used in earlier African studies. The shorter, rifamycin-based regimens had higher adherence rates than did the 6-month isoniazid regimen and did not appear to select for drug-resistant M. tuberculosis in the small number of isolates cultured. These results are consistent with an earlier study showing the efficacy of daily isoniazid and rifampin in adults with HIV infection, but we found that a twice-weekly regimen was also efficacious.


译文:
本研究发现三种新型预防方案与对照组相比在治疗HIV感染合并结核方面不存在优越性。总体结核年发病率为19%,治疗组与对照组相比无显著性差异。非洲地区未接受抗结核治疗的HIV感染合并结核皮试阳性患者,预计结核年发病率为5-10% 。对照组结核发病率明显低于预期值,表明本研究的治疗方案疗效高于既往非洲地区的研究。与对照组相比,基于短期服用异烟肼组患者坚持治疗率较高,且未筛检出抗药性菌株。既往研究证实HIV感染成年患者每日服用异烟肼与利福平具有一定功效,我们的结果与之相似。所不同的是,我们发现每周服药两次同样有效。


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