医学翻译样例
原文:
gd T cells are an important source of IL-17 upon high dose intratracheal BCG infection and low dose Mtb aerosol infection. In the BCG model, both IL-17 and gd T cell deficient mice show delayed granuloma formation, suggesting that gd T cell-derived IL-17 is essential for initial granuloma organiza- tion, probably by promoting early neutrophil recruitment. However, unlike in the BCG model, low dose aerosol Mtb infected gd T cell deficient mice display enhanced cellular foci with elevated accumulation of neutrophils. Antibody neutrali- zation of neutrophils in these mice reduces this exacerbated accumulation of cells further supporting the hypothesis that neutrophil accumulation promotes granuloma formation in the presence or absence of gd T cells. Taken together, these data suggest a differential role for IL-17 producing gd T cells in the low dose aerosol Mtb infection model versus the high dose intra-tracheal BCG model. Although initial cellular foci organization seems to be promoted by early neutrophil migration further research is required to understand the role of gd T cells in this process.
译文:
高剂量BCG感染或低剂量Mtb感染下,IL-17的重要来源均为γδT细胞。BCG模型中,IL-17与γδT缺陷小鼠肉芽肿形成延迟,表明γδT细胞来源的IL-17为肉芽肿形成的重要因素。该现象可能与促进早期嗜中性粒细胞招募相关。低剂量Mtb感染的γδT细胞缺陷小鼠细胞病灶内中性粒细胞积累量有所升高。嗜中性粒细胞抗体中和可降低细胞内嗜中性粒细胞积累,据此可推测嗜中性粒细胞积累可促进肉芽肿形成。这些表明,低剂量Mtb感染动物模型与高剂量BCG模型相比,产生IL-17的γδT细胞作用不同。 虽然早期嗜中性粒细胞前移可促进初期细胞病灶结构变化,但是要明确其中γδT细胞的作用还需要进一步研究。