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发布者:鑫达医学翻译 发布时间:2013-03-16 8:50:52 阅读:

原文:
Another potential mechanism of protection mediated by IL-17 against intracellular infections was recently identified.  Upon Francisella tularensis infection, the IL-23/Th17 axis was shown to enhance protection by promoting IL-12 secretion by DCs, therefore enhancing Th1 responses. This effect was shown to be directly mediated by IL-17 signaling, as culture of F. tularensis-stimulated DCs in the presence of IL-17, but not IL-17F or IL-22, induced a 10 fold increase in IL-12 levels. Moreover, differentiation of naive cells by F. tularensis-stimulated DCs  into IFN-g  producing cells was more efficient when IL-17 was added to the culture as compared to stimulated DCs alone. Altogether, these data show a novel role for IL-17 in intracellular infections. This novel IL-17 function is yet to be examined in  TB however, since Mtb is known to induce a strong IL-12 response IL-17 may be dispensable. Therefore, it is not surprising the observation that IL-17RA deficient mice are not more susceptible to low  aerosol infection.  Following high dose infection however, as IL-17 deficient are  more susceptible to Mtb, it is possible that IL-17 may act to enhance the protective immune response by  augmenting IL-12  secretion.

译文:
近期研究发现,IL-17可介导其他胞内感染预防机制。土拉热弗朗西丝菌感染后,IL-23/Th17可通过促进IL-12表达增强其对细胞的保护机制,进而增强Th1应答。 存在IL-17(而非IL-17F或IL-22)的条件下,土拉热弗朗西丝菌刺激的树突细胞内IL-12表达量升高10倍,这表明IL-17直接介导该保护机制。再者,添加IL-17后,土拉热弗朗西丝菌刺激树突细胞诱导的初始T细胞分化形成γ-干扰素细胞的数量大大增加。 这些表明,IL-17在胞内感染具有新的作用。 其作用仅在结核模型内进行了研究,但由于Mtb可诱导强烈的IL-12应答,所以IL-17是否真正与之相关还需要进一步确认。 因此,也就可以解释IL-17RA缺陷小鼠对低剂量喷雾感染并不敏感。然而,高剂量感染后IL-17缺陷小鼠对Mtb更敏感。推测IL-17可能会通过促进IL-12分泌增强保护性免疫性应答。


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