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发布者:鑫达医学翻译 发布时间:2013-04-06 8:50:52 阅读:

原文:
cultured chondrocytes generate atP through glycolysis and produce lactic acid as an end product. however, the capability of these cells to utilize oxidative metabolism for the production of chemical energy is supported by in vitro observations that chondrocytes contain mitochondrial dehydrogenases, that isolated mitochondria can utilize tricarboxylic acid (tca) cycle (also known as the citric acid cycle or Krebs cycle) substrates, and that these mitochondria contain the enzymes required for oxidative phosphorylation and electron transport. In addition, cultured human articular chondrocytes were shown to possess similar levels of enzymatic activity in the mitochondrial respiratory chain (mrc) when compared to other mesen chymal cells. Indeed, it has been reported that mitochondrial oxidative phosphorylation may account for as much as 25% of the atP production in cartilage. However, it is important to keep in mind that the majority of these results were obtained using in vitro models, which means that the chondrocytes are cultured in standard medium with high glucose concentrations (4.5 mm) and under aerobic conditions (high oxygen tension). interestingly, recent in vitro findings showed that hypoxia differentially modulates the chondrocyte proteome in normal and oa human chondrocytes, including some mitochondrial proteins. oa cells showed less-extensive modulation than normal chondrocytes, which indicates a lower capacity of diseased cells to react under a hypoxic milieu.


译文:
培养的软骨细胞通过糖酵解产生ATP,并形成终产物乳酸。然而,体外观察,包括软骨细胞含有线粒体脱氢酶、离体的线粒体能利用三羧酸(TCA)循环的底物、线粒体包含氧化磷酸化作用和电子传递所需的酶等表明,这些软骨细胞具有利用氧进行新陈代谢产生化学能的能力。另外,培养的人关节软骨细胞在线粒体呼吸链中与其他间质细胞具有相似的酶活性。有报道称,线粒体氧化磷酸化作用负责软骨中25%的ATP的产生,但是,值得一提的是,这些结果中大多数通过体外模型获得,也就是说,软骨细胞的培养条件为高葡萄糖浓度(4.5 mm)、高氧张力。有趣的是,最近的体外研究结果显示,正常软骨细胞和骨关节炎软骨细胞都能通过不同程度的缺氧来调整软骨细胞的蛋白质组,包括多种线粒体蛋白。骨关节炎细胞比正常软骨细胞可调整的范围要小,这表明,病变细胞在低氧环境中发挥作用的能力较低。


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