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医学翻译——轴突损伤

发布者:鑫达医学翻译 发布时间:2013-06-17 8:50:52 阅读:

原文:
For both motor and sensory NCSs, the hallmark of axonal loss is reduction in CMAP or SNAP amplitude (Fig. 5). Conduction velocities may be mildly slowed and distal latencies mildly prolonged, owing to selective loss of larger-diameter and therefore faster-conducting axons. These secondary changes in the speed of conduction become more prominent with more extensive axonal loss. Following acute axonal lesions, wallerian degeneration takes place on the order of days after the injury, over which time the loss of amplitude develops. For chronic, slowly progressive axonal disorders, reinnervation of denervated muscle fibers through axonal sprouting may result in preservation of CMAP amplitude until advanced stages of axonal loss. For most disorders that result in loss of both sensory and motor axons, SNAP amplitudes are affected earlier and more conspicuously. It is also important to recall that severe demyelination may result in secondary axonal loss.


译文:
针对运动及感觉神经传导,轴突损伤的标志为CMAP或SNAP振幅降低,如图5所示。传导速度有所降低,远端潜伏期有所延长,主要源于快速传导轴突受损。轴突损伤范围越大,传导速度变化越明显。急性轴突损伤后,会出现Waller变形,进而出现振幅降低。慢性轴突病变中,去神经肌肉纤维神经移植后可能导致CMAP振幅降低,进一步可导致轴突损伤。针对感觉与运动轴突损伤的疾病,SNAP振幅更容易在早期受到影响。因此,有必要明确严重的脱髓鞘可能导致次级轴突损伤。


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